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冠心病绝大多数由动脉粥样硬化引起,而动脉粥样硬化的形成与消退均与血浆脂蛋白有密切关系。近年上述两者的关系已不断得到阐明,不仅血浆低密度脂蛋白浓度的增高可引起动脉粥样斑块的形成,且高密度脂蛋白浓度的降低亦与动脉粥样斑块的产生有关。此外,低密度脂蛋白(LDL)受体缺陷已被认为是家族性高胆固醇血症的原因。本文以脂蛋白为中心就血脂与脂蛋白的关系、高脂蛋白血症,动脉粥样硬化病变的预防,动脉粥样斑块的消退等四个方面探讨了动脉粥样硬化的发病原理与冠心病的防治问题。
The vast majority of coronary heart disease caused by atherosclerosis, and the formation and regression of atherosclerosis are closely related with plasma lipoprotein. In recent years, the relationship between the two has been constantly elucidated. Not only the increase of plasma LDL concentration can cause the formation of atherosclerotic plaque, but also the decrease of HDL concentration is related to the production of atherosclerotic plaque. In addition, low density lipoprotein (LDL) receptor defects have been identified as the cause of familial hypercholesterolemia. In this paper, lipoprotein as the center on the relationship between lipids and lipoprotein, hyperlipoproteinemia, prevention of atherosclerotic lesions, atherosclerotic plaque regression four aspects of the pathogenesis of atherosclerosis and the crown Heart disease prevention and control problems.