肝癌(HCC)是我国常见的恶性肿瘤之一,以其高发病率和高度恶性行为而著称。肿瘤的形成与发展与细胞自身基因突变所导致的原癌基因激活和/或抑癌基因失活有关,同时还受肿瘤细胞所处微环境变化的影响。细胞外基质(ECM)不仅是细胞赖以生存的场所,而且是细胞与细胞之间自分泌和旁分 Liver cancer (HCC) is one of the common malignant tumors in our country, known for its high morbidity and high malignant behavior. The formation and development of tumor are related to the activation of protooncogene and / or inactivation of tumor suppressor gene caused by mutation of cell itself, and are also influenced by the change of microenvironment in tumor cells. Extracellular matrix (ECM) is not only a place for cells to survive, but also between cells and cells autocrine and para