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自1785年洋地黄应用于临床以来,迄今已近200年历史,目前仍是心脏病治疗中,特别是治疗心力衰竭的主要药物。但由于近代快速强利尿剂以及提纯的洋地黄制剂的应用,洋地黄中毒的相对和绝对发生率都有所增加。中毒患者中约3～21％因心脏中毒而死亡。而传统的洋地黄化法(饱和量法或负荷法)是引起中毒发生率高的主要原因。因此有人认为改变洋地黄的用法可以明显地减低洋地黄中毒的发生率与死亡率。我院近三年来用随机分组的方法将有用地高辛适应症的住院患者分为两组:一组用饱和量疗法(缓给法)进行治疗,一组用
Since 1785, digitalis has been used clinically for nearly 200 years and is still the main drug for heart disease treatment, especially for the treatment of heart failure. However, the relative and absolute incidence of digitalis poisoning has increased due to the recent rapid diuretics and purified digitalis formulations. About 3 ~ 21% of poisoned patients died of heart poisoning. The traditional method of digitalis (saturation method or load method) is the main cause of the high incidence of poisoning. Therefore, some people think that the use of digitalis can significantly reduce the incidence of digitalis poisoning and mortality. In the past three years, our hospital divided randomly the inpatients with digoxin indications into two groups by means of randomization: one was treated with saturation therapy (slow delivery)