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目的探讨携带9号染色体臂间倒位对体外授精和卵胞浆内单精子显微注射(IVF/ICSI)新鲜取卵周期临床结局的影响。方法本研究纳入本中心2010年5月-2016年3月47例9号染色体臂间倒位患者共50个新鲜取卵周期。当天非9号染色体臂间倒位患者作为对照组。观察获卵数、正常受精卵数、胚胎数、移植胚胎数、临床妊娠率、种植率、异位妊娠率、多胎妊娠率、流产率、活产率、足月产率、新生儿男女性别比和新生儿缺陷/疾病发生率等指标。结果观察组获卵数、正常受精卵数、胚胎数、移植胚胎数、临床妊娠率、种植率、异位妊娠率、多胎妊娠率、流产率、活产率、足月产率、新生儿男女性别比和新生儿缺陷/疾病发生率等指标与对照组没有显著差异(P>0.05)。结论 9号染色体臂间倒位不影响IVF/ICSI新鲜周期的临床结局。
Objective To investigate the effect of carrying arm 9 inversions on the clinical outcome of IVF / ICSI fresh ovulation cycles in vitro fertilization and intracytoplasmic sperm injection. Methods This study was included in the center from May 2010 to March 2016 47 cases of chromosome 9 inversions between arm patients a total of 50 fresh oocyte retrieval cycles. The same day non-9 chromosome inversion patients as a control group. Observe the number of oocytes, the number of normal fertilized eggs, the number of embryos, the number of embryos transferred, clinical pregnancy rate, implantation rate, ectopic pregnancy rate, multiple pregnancy rate, abortion rate, live birth rate, full-term birth rate, neonatal sex ratio And neonatal defects / disease incidence and other indicators. Results The number of oocytes retrieved, number of normal fertilized eggs, number of embryos, number of embryos transferred, clinical pregnancy rate, implantation rate, ectopic pregnancy rate, multiple pregnancy rate, abortion rate, live birth rate, full-term birth rate, Sex ratio and neonatal defect / disease incidence and other indicators and the control group no significant difference (P> 0.05). Conclusion Inversion of chromosome 9 on the arm does not affect the clinical outcome of the IVF / ICSI fresh cycle.