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目的:观察清热解毒方对腹腔感染大鼠血清内毒素及细胞因子水平的影响。方法:Wistar大鼠随机分为4组:对照组、模型组、清热解毒方组、头孢克肟组,ig1次,给药30 min后大肠杆菌ip造成大鼠急性细菌性腹膜炎模型,于6,12,18,24 h后分别检测各组动物血浆内毒素,肿瘤坏死因子α(TNF-α),IL-6,IL-10水平。结果:造模后模型组大鼠血清内毒素,TNF-α,IL-6,IL-10较对照组明显升高(P<0.01),清热解毒方组与头孢克肟组上述指标较模型组明显降低。结论:清热解毒方能有效降低大肠杆菌腹腔感染大鼠血清内毒素及TNF-α,IL-6,IL-10水平。
Objective: To observe the effect of Qingrejiedu Prescription on serum endotoxin and cytokines in rats with intraperitoneal infection. Methods: Wistar rats were randomly divided into 4 groups: control group, model group, Qingrejiedu group, cefixime group, ig1 times, 30 min after administration of E. coli ip caused acute bacterial peritonitis model in rats, The levels of plasma endotoxin, tumor necrosis factor-α (TNF-α), IL-6 and IL-10 in each group were detected after 12, 18 and 24 hours. Results: Compared with the control group, the levels of serum endotoxin, TNF-α, IL-6 and IL-10 in the model group were significantly increased (P <0.01). The above indexes of Qingrejiedu Fang group and cefixime group were significantly higher than those of model group Obvious reduction. Conclusion: Qingrejiedu Decoction can effectively reduce the levels of serum endotoxin, TNF-α, IL-6 and IL-10 in rats with abdominal infection of Escherichia coli.