越来越多的证据表明与兴奋性毒性神经损害有关的谷氨酸释放在局灶性脑缺血的发病机理中起着关键作用。拮抗谷氨酸异常蓄积的药物能减小实验性卒中的梗塞面积。实验中谷氨酸拮抗剂的应用是基于卒中后兴奋性毒性持续至少数小时的假设,由于缺少人类兴奋性氨基酸释放持续时间的研究,也就难以确定谷 There is growing evidence that glutamate release, associated with excitotoxic damage, plays a key role in the pathogenesis of focal cerebral ischemia. Antagonists of glutamate abnormal accumulation of drugs can reduce the infarct size of experimental stroke. The use of glutamate antagonists in experiments has been based on the assumption that post-stroke excitotoxicity persists for at least a few hours and that the lack of studies on the duration of human excitatory amino acid release also makes it difficult to determine the