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应用 LTG 添加,开放性自身对照法,观察难治性癫痫30例,观察时间12～24周。结果:12周末,显效9例(30%),有效4例,总有效率43.3%。16～24周获类似的结果。LTG 对各型癫痫发作均有一定效果,似对 GTCS 和 Abs 疗效更佳,EEG 有改善的趋向。副反应轻,主要为皮疹(18.8%)、头晕、头痛、困倦、复视及恶心,除2例因副作用停药(皮疹1例,原精神兴奋复发1例),余多自行消退,治疗前后各项实验室检查均未见有临床意义的异常变化。
Thirty patients with refractory epilepsy were treated with LTG and open self-control method. The observation time ranged from 12 to 24 weeks. Results: At the end of 12 weeks, 9 cases (30%) were markedly effective and 4 cases were effective. The total effective rate was 43.3%. A similar result was obtained between 16 and 24 weeks. LTG on each type of seizures have some effect, it seems better for GTCS and Abs, EEG have an improved trend. Side effects were mild, mainly rash (18.8%), dizziness, headache, drowsiness, diplopia and nausea. Except for 2 cases whose side effects were discontinued (skin rash occurred in 1 case and original spirit excitated recurrence in 1 case) None of the laboratory tests showed clinically significant abnormal changes.