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本文观察了一次性经腹腔注射氯乙醇（３０ｍｇ／ｋｇＢ．Ｗ．）的急性染毒大鼠３，６，１２，２４ｈ等四个不同时点肝脏的超氧化物歧化酶、谷胱甘肽过氧化物酶等抗氧化酶活力及脂质过氧化物—丙二醛含量的变化关系，结果发现氯乙醇急性染毒组肝脏中上述的抗氧化酶活性于所设四个时点中均比对照组低（Ｐ＜０．０１及０．０５），而同时丙二醛含量高于对照组（Ｐ＜０．０１及０．０５），提示氯乙醇急性染毒大鼠中肝脏抗氧化酶活性受氯乙醇毒性所抑制，出现肝脏脂质过氧化并造成肝损害。同时，本文也发现氯乙醇急性染毒大鼠血清中丙二醛含量与肝脏丙二醛含量存在着高度密切的正相关关系（Ｐ＜０．０１），且血清中丙二醛含量比谷丙转氨酶活性早升高，提示血清丙二醛可能可以作为检测氯乙醇急性肝损害较为敏感的指标
This article observed a single intraperitoneal injection of chloroethanol (30mg / kgB.W.) Acute exposure to rats 3,6,12,24 h at four different time points in the liver superoxide dismutase, glutathione Oxidase and other antioxidant enzymes and lipid peroxides - malondialdehyde content changes, the results found that acute exposure to chloroethanol in the liver of the above antioxidant enzyme activity in the set four points than the control (P <0.01 and 0.05), while at the same time the content of malondialdehyde was higher than that of the control group (P <0.01 and 0.05), suggesting that the activities of antioxidant enzymes in the liver of rats exposed to chloroethanol Inhibited by the toxicity of chloroethanol, liver lipid peroxidation and liver damage. At the same time, this paper also found that acute exposure to chloroethanol serum malondialdehyde content and liver malondialdehyde content there is a highly positive correlation (P <0.01), and serum malondialdehyde content than Valley Aminotransferase activity increased early, suggesting that serum malondialdehyde may be used as a sensitive indicator of acute liver injury detection of chloroethanol