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目的:研究丙丁酚对冠心病患者及其高危人群内皮依赖性血管舒张功能(FMD)的调节作用,探讨丙丁酚在抗动脉粥样硬化中的作用和价值。方法:观察28例冠心病患者(A组)及25例高血压伴高血脂患者(B组)服用丙丁酚1周前后血脂值及FMD,同时检测30例健康对照者(C组)血脂值和FMD,检测FMD采用高分辨率血管超声法。结果:A、B组用药前后自身对照血脂值差异无统计学意义。A、B组较C组肱动脉内径基础值D0及FMD均明显降低(P<0·05,P<0·01),用药后2组D0值较前稍改善(P<0·05,),FMD显著改善(P<0·01),2组间比较,未发现D0和FMD差异有统计学意义。结论:冠心病患者和其高危人群FMD明显降低,丙丁酚显著改善血管内皮功能,该作用不依赖于血脂调节,提示其作为目前被发现的最强的抗氧化剂之一,可作用于动脉粥样硬化的关键环节,使动脉粥样硬化从根本上得到改善。
OBJECTIVE: To study the regulatory effect of probucol on endothelium-dependent vasodilation (FMD) in patients with coronary heart disease and its high-risk population and to explore the role and the value of probucol in anti-atherosclerosis. Methods: The blood lipids and FMD in 28 patients with coronary heart disease (A group) and 25 hypertensive patients with hyperlipidemia (B group) before and after taking probucol were observed. The serum lipids of 30 healthy controls (C group) and FMD, detection of FMD using high-resolution vascular ultrasound. Results: There was no significant difference in self-control blood lipids between group A and group B before and after treatment. The values of D0 and FMD in group A and group B were significantly lower than those in group C (P <0.05, P <0.01) , FMD was significantly improved (P <0.01). There was no significant difference in D0 and FMD between the two groups. CONCLUSION: FMD is significantly decreased in patients with coronary heart disease and in high-risk groups. Probucol has a significant effect on vascular endothelial function, which is independent of lipid regulation, suggesting that it is one of the strongest anti-oxidants found and may play an important role in atherosclerosis The key to hardening, atherosclerosis fundamentally improved.