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分子生物学、微穿刺和微灌注等技术的联合应用研究对于阐明H+ ,K+ ATP酶的分子结构与功能表达已取得了一定的认识 ,并对其亚型转运体的性质也有了足够的了解 ,且已克隆出大部分亚型的转运体。本文对H+ ,K+ ATP酶及亚型分布结构、表达调节、生化特性以及在肾脏生理、病理过程中所发挥的重要作用机制进行综述
The combined application of molecular biology, micro-puncture and micro-perfusion technology has made some understanding of the molecular structure and functional expression of H +, K + ATPase, and also has a sufficient understanding of the properties of its subtype transporters, Most subtypes of transporters have been cloned. This review summarizes the distribution and regulation of H +, K + ATPase and its subtypes, the regulation of their expression, their biochemical properties, and their important roles in the physiology and pathology of the kidney