Flight vehicle conceptual design appears to be a promising area for application of the Genetic Algorithm (GA) as an approach to help to automate part of the design process. This computational research effort strives to develop a propulsion system design strategy for liquid rocket to optimize take-off mass, satisfying the mission range under the constraint of axial overload. The method by which this process is accomplished by using GA as optimizer is outlined in this paper. Convergence of GA is improved by introducing initial population based on Design of Experiments Technique. Flight vehicle conceptual design appears to be a promising area for application of the Genetic Algorithm (GA) as an approach to help to automate part of the design process. This computational research effort strives to develop a propulsion system design strategy for liquid rocket to optimize take -off mass, satisfying the mission range under the constraint of axial overload. The method by which this process is accomplished by using GA as optimizer is outlined in this paper. Convergence of GA is improved by introducing initial population based on Design of Experiments Technique.