胰腺癌是较常见的消化系统恶性肿瘤之一 ,在西方国家的发病率为 12 .5 /10万 ,患者病死率超过 97% [1] 。近 2 0年来 ,胰腺癌在治疗上进展甚微 ,关键问题大部分患者确诊时已属晚期 ,失去手术切除的机会[2 ,3] 。胰腺癌根治性手术切除率仅在 18%左右[4 ] 。胰腺癌患者的自然病程 Pancreatic cancer is one of the more common malignant tumors of the digestive system, with a prevalence of 12.5 / 100,000 in Western countries and a patient-mortality rate of more than 97% [1]. In the past 20 years, there has been little progress in the treatment of pancreatic cancer. Most of the key problems are already diagnosed at the advanced stage, losing the chance of surgical resection [2,3]. Radical resection of pancreatic cancer surgery rate was only about 18% [4]. Natural history of patients with pancreatic cancer