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为了探讨海马硬化与癫痫的因果关系，选用Ｗｉｓｔａｒ大鼠以马桑内酯肌肉注射，制成全身强直－阵挛性发作的癫痫动物模型，并于点燃后连续用药，分别引起Ⅳ级以上抽搐发作２０和４０次。同时建立生理盐水和安定对照组，后者于注射马桑内酯前注射安定，以避免抽搐。并对海马ＣＡ１区进行病理形态学观察。结果显示，马桑内酯注射组与安定组大鼠海马ＣＡ１区有明显的病理改变，锥体细胞变性坏死，神经胶质细胞水肿变性，突触结构异常。抽搐４０次组病理变化重于抽搐２０次组，后者又重于安定组。生理盐水组未见上述改变。结果提示，马桑内酯可引起大鼠海马ＣＡ１区神经元损伤，既使无抽搐发作时也可造成这种损伤。反复严重的抽搐发作又可进一步加重海马ＣＡ１区的病损，抽搐次数越多，损伤越重。海马硬化可能是抽搐反复发作造成的结果。
In order to explore the causal relationship between hippocampal sclerosis and epilepsy, Wistar rats were intramuscularly injected with docetaxel to make a model of epilepsy with generalized tonic-clonic seizures. After continuous burning, Wistar rats were induced seizure above grade IV 20 and 40 times. At the same time, saline and diazepam groups were established, and the latter was injected with diazepam prior to injection of corundum to avoid convulsions. The pathological changes of hippocampal CA1 region were observed. The results showed that there were obvious pathological changes in hippocampal CA1 region of corundum injection group and diazepam group, degeneration and necrosis of pyramidal cells, glial cell edema degeneration and synaptic structure abnormalities. Twitch group 40 times more pathological changes than twitch 20 times, the latter is heavier than the stability group. Saline group did not see the above changes. The results suggest that the intramuscular lactone can cause neuronal damage in the hippocampal CA1 region of the rat, even in the absence of seizures. Severe convulsions and seizures can further aggravate the lesions in the hippocampal CA1 area, the more convulsions, the more serious injury. Hippocampal sclerosis may be the result of recurrent seizures.