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目的探讨内生场热疗对食管癌放疗患者的急性放射反应及T细胞亚群的影响。方法22例病理确诊的食管癌患者随机分成2组:内生场热疗+放疗治疗组;放疗组(对照)。用钴60治疗机常规放射治疗,DT 60~66 Gy/30~33 F;综合组加内生场热疗,2 F/W,8~10 F。流式细胞仪检测治疗前后患者外周血T细胞亚群。结果综合组疗初和疗终时T细胞亚群:CD4+、CD8+、CD4+/CD8+变化均无显著意义(P>0.05);单放组疗初和疗终时T细胞亚群:CD4+下降(P<0.05),CD4+/CD8+下降(P<0.01),CD8+变化不明显(P>0.05)。与对照组比较,急性放射反应减轻。结论内生场热疗可能减轻食管癌患者的急性反应,改善放疗所致的T细胞亚群紊乱。
Objective To investigate the effects of endogenous hyperthermia on acute radiation response and T cell subsets in esophageal cancer patients undergoing radiotherapy. Methods Twenty-two patients with pathologically diagnosed esophageal cancer were randomly divided into two groups: endogenous hyperthermia + radiotherapy group and radiotherapy group (control group). Radiotherapy with cobalt 60 conventional radiotherapy, DT 60 ~ 66 Gy / 30 ~ 33 F; combined group plus endogenous hyperthermia, 2 F / W, 8 ~ 10 F. Flow cytometry was used to detect peripheral blood T lymphocyte subsets in patients before and after treatment. Results The T cell subsets at the end of the initial and final treatment were not significantly different between the two groups (P> 0.05). The level of CD4 + <0.05), CD4 + / CD8 + decreased (P <0.01) and CD8 + did not change significantly (P> 0.05). Compared with the control group, the acute radiation response was relieved. Conclusion Endogenous hyperthermia may reduce the acute response in patients with esophageal cancer and improve the disturbance of T lymphocyte subsets caused by radiotherapy.