论文部分内容阅读
目的：探讨ｐ５３ 、ｎｍ ２３ 基因在喉鳞癌中的异常表达与预后的关系。方法：应用免疫组织化学方法对３９例喉鳞癌石蜡标本进行ｐ５３ 蛋白、ｎｍ ２３ 蛋白检测。结果：１８ 例（４６－１ ％ ） 喉癌呈ｐ５３ 过度表达；２９ 例（７４－４％ ） 喉癌呈ｎ ｍ２３ 阳性表达。ｐ５３ 蛋白的阳性过度表达与ｎ ｍ２３ 阳性表达与喉癌的临床分期、颈淋巴结转移及５ 年生存率密切相关。结论：ｐ５３ 蛋白、ｎｍ ２３ 蛋白表达可作为临床预测喉癌颈淋巴结转移及预后的重要参考指标。
Objective: To investigate the relationship between the abnormal expression of p53 and nm23 genes in laryngeal squamous cell carcinoma and its prognosis. Methods: Immunohistochemistry was used to detect p53 protein and nm23 protein in 39 paraffin-embedded specimens of laryngeal squamous cell carcinoma. Results: Eighteen (46-10%) cases of laryngeal carcinoma were overexpressed p53, and 29 cases (74-4%) of laryngeal carcinoma were positive for n m23. The positive expression of p53 protein and the positive expression of n m23 were closely related to the clinical stage, lymph node metastasis and 5-year survival rate of laryngeal cancer. Conclusion: The expression of p53 protein and nm23 protein can be used as an important reference index for predicting cervical lymph node metastasis and prognosis in laryngeal cancer.