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目的探讨极低出生体重新生儿发生支气管肺发育不良(BPD)的临床危险因素。方法选取我院收治的极低出生体重新生儿189例,按照发生BPD情况分为BPD组和非BPD组,对其临床资料进行回顾性分析,分析发生BPD的危险因素。结果本组BPD发生率为24.33%,其中孕周、新生儿出生体重、胎膜早破、颅内出血、母亲产前感染史、NRDS、使用肺表面活性物质、机械通气、使用呼吸机时间、吸氧时间与BPD的发生密切相关。结论低胎龄、低出生体重、NRDS、母亲产前感染史、长时间机械通气以及高浓度吸氧是BPD发生的危险因素,预防早产和孕妇感染,同时采取保护性通气策略对于降低BPD发生率具有重要临床意义。
Objective To investigate the clinical risk factors of bronchopulmonary dysplasia (BPD) in very low birth weight infants. Methods A total of 189 neonates with very low birth weight who were admitted to our hospital were divided into BPD group and non-BPD group according to the occurrence of BPD. The clinical data were analyzed retrospectively to analyze the risk factors of BPD. Results The incidence of BPD in this group was 24.33%, including gestational age, birth weight, premature rupture of membranes, intracranial hemorrhage, history of mother’s prenatal infection, NRDS, pulmonary surfactant, mechanical ventilation, ventilator time, Oxygen time and the occurrence of BPD are closely related. Conclusions Low gestational age, low birth weight, NRDS, mothers’ prenatal infection history, prolonged mechanical ventilation and high concentration of oxygen are the risk factors for BPD. Prevention of preterm birth and pregnant women infection, and protective ventilation strategy to reduce the incidence of BPD Has important clinical significance.