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目的研究胃食管反流患者的食管下括约肌压力(LESP)及胃电图的变化。方法检测胃食管反流患者(分为症状性反流和反流性食管炎)及对照组的LESP和胃肌电活动的频率及振幅。结果症状性反流及反流性食管炎患者的LESP均明显低于对照组;胃食管反流患者的胃肌电活动频率显著低于对照组;胃肌电频率正常者的LESP高于频率降低者。结论 LESP低下者易发生胃食管反流;症状性反流应作为胃食管反流病(GERD)的一个阶段;异常的胃肌电活动与食管下括约肌功能的减退及胃食管反流病的发生有关。
Objective To study the changes of esophageal sphincter pressure (LESP) and electrogastrogram in patients with gastroesophageal reflux disease. Methods The frequency and amplitude of LESP and gastric myoelectrical activity in patients with gastroesophageal reflux (divided into symptomatic reflux and reflux esophagitis) and control group were detected. Results The LESP of patients with symptomatic reflux and reflux esophagitis was significantly lower than that of the control group. The gastric myoelectrical activity was significantly lower in patients with gastroesophageal reflux than those in the control group. The LESP in patients with normal gastroesophageal reflux was higher than that in controls By. Conclusions Gastroesophageal reflux is easy to occur in those with low LESP. Symptomatic reflux should be a stage of gastroesophageal reflux disease (GERD). Abnormal gastric myoelectrical activity and esophageal sphincter dysfunction and gastroesophageal reflux disease related.