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高密度脂蛋白(HDL)保护血管的主要活性成分载脂蛋白AⅠ和磷酸鞘氨醇1的细胞表面受体皆存在于脂肪组织,而参与HDL重构的脂质转运蛋白亦在脂肪组织高表达,提示HDL可以通过上述成分调节脂肪细胞能量代谢.相关分子机制研究发现,健康人体内和重组的HDL颗粒皆可活化脂肪细胞腺苷酸激活蛋白激酶(AMPK),并抑制脂肪酸氧化,而体外和体内实验均证明HDL可能通过其主要活性成分的多个受体途径协调激活AMPK活性,从而参与调节脂肪细胞能量代谢.期待HDL对脂肪细胞AMPK的调节作用研究能为防治脂肪代谢异常所致肥胖性疾患提供新的治疗靶点.
High-density lipoprotein (HDL) to protect the blood vessels of the main active ingredients apolipoprotein A Ⅰ and sphingosine 1 cell surface receptors are present in adipose tissue, and involved in the HDL remodeling of lipid transporters are also highly expressed in adipose tissue , Suggesting that HDL can regulate the energy metabolism of adipocytes.Related molecular mechanisms study found that healthy human and recombinant HDL particles can activate adipocyte adenylate activated protein kinase (AMPK), and inhibit fatty acid oxidation, while in vitro and in vivo In vivo experiments show that HDL may coordinate the activation of AMPK activity through multiple receptor pathways of its major active ingredients and thus participate in the regulation of the energy metabolism of adipocytes.It is hoped that the regulation of HDL on AMPK in adipocytes will be of great benefit in the prevention and treatment of obesity caused by abnormal fat metabolism Disorders provide new therapeutic targets.