论文部分内容阅读
背景 过敏性疾病自 2 0世纪后叶迅速增加 ,其治疗药物随之上市。但大量临床研究并未明确药物治疗效果和经济学特性好坏 ,药物严重不良反应的出现给临床用药和国家基本药物遴选带来困难。目的 运用卫生技术评估方法 ,评价阿司咪唑、氯雷他丁、西替利嗪和特非那定治疗过敏性鼻炎、荨麻疹的有效性 ,心脏不良反应和经济学特性。检索策略 数据库包括Cochrane图书馆、Medline、Embase和中文生物医学数据库 ,安全性和经济学另检索相关数据库。选择标准 中文或英文研究。 1)有效性 :四种抗变态反应药物中的两种或以上用于过敏性鼻炎和荨麻疹的系统评价 /meta -分析和高质量随机对照试验 ;2 )安全性 :四种抗变态反应药物用于各种变态反应性疾病后出现心脏不良反应的各种级别的证据 ;3)经济学特性 :四种抗变态反应药物中的两种或以上用于过敏性鼻炎、荨麻疹的成本 -效果和成本 -效用的研究。评价方法 设计质量评价和资料提取表。系统评价和随机对照试验分别使用QUOROMSTATEMENT和Jadad评价表评价研究质量。两名评价者独立选择文献、评价研究质量和提取原始资料 ,不同意见经讨论解决。数据分析 Revman 4 .1使用固定效应模型分析原始数据 ,敏感性分析解决研究间异质性 ,若仍有异质性使用随机效应模型。
Background Allergic diseases have rapidly increased since the turn of the 20th century and their therapeutic drugs have become available. However, a large number of clinical studies have not made it clear whether the drug treatment and economic characteristics are good or not. The emergence of serious adverse drug reactions poses difficulties for the clinical use of drugs and the selection of national essential medicines. Objectives To assess the effectiveness of astemizole, loratadine, cetirizine, and terfenadine in the treatment of allergic rhinitis, urticaria, adverse cardiac reactions and economic characteristics using the technique of health assessment. The search strategy database includes the Cochrane Library, Medline, Embase and Chinese Biomedical Databases, as well as other relevant databases of safety and economics. Choose standard Chinese or English study. 1) Validity: Systematic reviews / meta-analyzes and high-quality randomized controlled trials of two or more of the four anti-allergic drugs for allergic rhinitis and urticaria; 2) Safety: Four anti-allergic drugs Various levels of evidence of cardiac adverse reactions after various allergic diseases; 3) Economic characteristics: Cost-effectiveness of two or more of the four anti-allergic drugs for allergic rhinitis, urticaria And cost-utility research. Evaluation method Design quality evaluation and data extraction table. Systematic reviews and RCTs used the QUOROMSTATEMENT and Jadad evaluation tables to evaluate the quality of the study. Two reviewers independently selected the literature, evaluated the quality of the research and extracted the original materials. Different opinions were discussed and resolved. Data Analysis Revman 4 .1 Analyzes raw data using a fixed-effect model, sensitivity analysis addresses inter-study heterogeneity, and if there is still heterogeneity using a random-effects model.