急性胰腺炎(acute pancreatitis,AP)是一种临床常见疾病,其中重症急性胰腺炎(severe acute pancreatitis,SAP)因发病机制复杂,病死率高,并发症多而成为临床医学的一大难题。AP 的发病机制研究近年虽取得一些进展,但仍未完全阐明,先后提出了 Opie 学说(“共同通道学说”)、十二指肠返流学说、胰胆管梗阻学说、白细胞过度激活学说及微循环障碍学说等。1862年,Panum 就已注意到胰腺微循环与 AP 的关 Acute pancreatitis (AP) is a common clinical disease. Severe acute pancreatitis (SAP) is a major clinical problem because of its complicated pathogenesis, high mortality and many complications. Although some progress has been made in the study of pathogenesis of AP, the Opie theory (“Common Channel Theory”), duodenal reflux theory, pancreaticobiliary duct obstruction theory, leukocyte over activation theory Microcirculation theory and so on. In 1862 Panum noticed the close relationship between pancreatic microcirculation and AP