本部分实验中,我们将腺病毒介导的M-CSF和/或IFN-γ基因转染的巨噬细胞与肿瘤抗原共孵育,以发挥其抗原提呈功能而使巨噬细胞在回输体内前就获得诱导特异性抗肿瘤免疫功能的能力,进一步用此巨噬细胞治疗了实验性肺转移黑色素瘤小鼠,观察了其疗效并检测了经治疗后荷瘤小鼠的体内抗肿瘤免疫功能. In this part of the experiment, we used adenovirus-mediated macrophages transfected with M-CSF and/or IFN-γ genes to co-incubate with tumor antigens to exert their antigen-presenting function and allow macrophages to regenerate in vivo. The ability to induce specific anti-tumor immunity was obtained before, and mice with experimental lung metastasis melanoma were further treated with this macrophage, their efficacy was observed, and the in vivo antitumor immunity of the tumor-bearing mice after treatment was examined. .