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目的 比较肠外营养与肠内营养对胃癌病人术后细胞免疫功能的影响。方法 45例胃癌病人随机分为 2组 ,其中肠外营养 (PN)组 2 3例 ,肠内营养 (EN)组 2 2例。术后第 1天开始行肠外或肠内营养支持 ,时间 1周 ,检测术前和术后第 8天外周血T淋巴细胞亚群 (CD+ 3、CD+ 4、CD+ 8)和NK细胞活性等细胞免疫指标。结果 PN组术后CD+ 3、CD+ 4水平和NK细胞活性明显下降 ,CD+ 8水平明显升高 ;而EN组术后CD+ 3、CD+ 4、CD+ 8水平和NK细胞活性与术前相比无显著性变化。结论 肠外营养对胃癌病人术后细胞免疫功能无明显改善作用 ,而肠内营养有明显的细胞免疫增强作用 ,可有效地纠正胃癌病人术后细胞免疫抑制状态
Objective To compare the effects of parenteral nutrition and enteral nutrition on postoperative cellular immune function in patients with gastric cancer. Methods Forty-five patients with gastric cancer were randomly divided into 2 groups, including 23 cases in PN group and 22 cases in enteral nutrition group. Parenteral or enteral nutrition support was given on the first postoperative day for one week, and T lymphocyte subsets (CD + 3, CD + 4, CD + 8) and NK cell activity were measured before and 8 days after operation Cellular immunity indicators. Results The levels of CD + 3, CD + 4 and NK cells in PN group decreased significantly and the level of CD + 8 increased significantly. However, the levels of CD + 3, CD + 4, CD + 8 and NK cell in EN group were not significantly different from those before operation Sexual change. Conclusion Parenteral nutrition has no significant effect on postoperative cellular immune function in patients with gastric cancer, while enteral nutrition has obvious cellular immune enhancement effect, which can effectively correct postoperative cellular immunosuppression status of gastric cancer patients