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S100A13属于钙结合蛋白家族的成员。成纤维细胞生长因子1(FGF-1)不能通过经典的内质网-高尔基体途径释放。但FGF-1与S100A13可结合成多蛋白释放复合体,实现跨磷脂膜的出胞转运,而发挥其生物学作用。S100A13与FGF-1在肿瘤及心血管疾病中均有表达,在疾病的病理过程中有重要作用。
S100A13 belongs to the calcium binding protein family. Fibroblast growth factor 1 (FGF-1) can not be released by the classical endoplasmic reticulum-Golgi pathway. However, FGF-1 and S100A13 can be combined into a multi-protein release complex, transcellular phospholipid membrane transport, and play its biological role. S100A13 and FGF-1 are expressed in both tumor and cardiovascular diseases and play an important role in the pathological process of the disease.