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静脉注射免疫球蛋白(IVIG)是混合正常多种特异性免疫球蛋白G的治疗制剂。作者曾对几种商品IVIV制剂存在抗磷脂和抗DNA的自身抗体(Auto-Abs)及其体内致病的可能性进行了研究。作者用ELISA对IVIG制剂中Auto-Abs和抗独特型抗体的存在进行了检验。用IVIG制剂和用抗心磷脂(CL)或抗DNA的致病性单抗(mAbs)主动免疫幼鼠,试图引起自身免疫状态,然
Intravenous immunoglobulin (IVIG) is a therapeutic agent that mixes well with a variety of specific immunoglobulin G’s. The authors studied the presence of anti-phospholipid and anti-DNA auto-Abs in several commercial IVIV formulations and their potential for in vivo pathogenesis. The authors tested the presence of Auto-Abs and anti-idiotypic antibodies in IVIG formulations by ELISA. Active immunization of young rats with IVIG formulations and with anti-cardiolipin (CL) or anti-DNA pathogenic monoclonal antibodies (mAbs) is an attempt to elicit an autoimmune condition