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双氯灭痛２０，４０ｍｇ／ｋｇ降低肝脏巨噬细胞对碳粒的吞噬能力，于抗原致敏后给药，显著抑制绵羊红细胞诱导的小鼠迟发型座垫肿胀及氯化锆诱导的小鼠接触性皮炎，而抗原攻击同时及其后１６ｈ给药仅是抑制趋势；双氯灭痛４０ｍｇ／ｋｇ降低小鼠血清溶血素含量及脾脏巨噬细胞的吞噬功能。上述结果提示双氯灭痛对机体细胞免疫、体液免疫功能及单核巨噬系统的吞噬能力均具有抑制作用。
Diclofenac 20 and 40 mg / kg decreased the phagocytosis of carbon particles by liver macrophages, which were administered after the antigen was sensitized, significantly inhibited the swelling of delayed cushion of mice induced by red blood cells of sheep and zirconyl chloride-induced mouse contact dermatitis , While the antigen challenge at the same time and 16h after administration only inhibit the trend; diclofenac 40mg / kg reduce serum hemolysin levels and phagocytic function of spleen macrophages. The above results suggest that diclofenac inhibits cellular immunity, humoral immune function and phagocytic ability of mononuclear macrophage system.