苯二氮(艹卓)类(下简称BZ)药物在人体产生药物依赖性虽需较长时间,但产生依赖性是肯定的。BZ药物产生依赖性的最短时间是在持续用药3个月,多数报道至少6个月,通常在多年后出现停药反应。服用安定达6个月以上的患者,药物依赖性的发生率约为30%。Rickcls等报告在双盲观察下,骤停安定而以安慰剂代替后的断药症状,病人用药在1年以内者,发生率为9%;用药1年以上者,发生率为57%。 Benzodiazepines (BZ) class (hereinafter referred to as BZ) drugs in the human body to produce drug dependence although longer time, but the dependence is positive. The shortest duration of BZ drug dependence dependence is sustained for 3 months, most reported for at least 6 months, and usually stopped after many years of withdrawal. Patients taking Diazepam for more than 6 months have a 30% incidence of drug dependence. Rickcls et al. Reported a discontinuation of placebo in a double-blind study, with discontinuation of medication discontinued. The patient’s medication was within 1 year at a rate of 9%; for a period of more than 1 year, the rate was 57%.