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本文报告了用同种异体骨髓移植法治疗24例多发性骨髓瘤(MM),其中男11例,女13例,年龄平均39岁.IgG型8例,IgA型8例,IgD型1例,本周氏蛋白阳性6例,非分泌型1例.确定诊断时Ⅰ期5例,Ⅱ期4例,Ⅲ期14例,浆细胞白血病1例.移植时Ⅰ期8例,Ⅱ期3例,Ⅲ期12例,浆细胞白血病获完全缓解.移植前均接受化疗.骨髓移植方案虽不尽相同,但都经全身照射和化疗.预防GVHD包括单独或联合应用MTX、CsA、McAb去除供者T细胞和强的松.
This article reports the use of allogeneic bone marrow transplantation in the treatment of 24 patients with multiple myeloma (MM), including 11 males and 13 females, mean age 39. IgG in 8 cases, IgA in 8 cases, IgD in 1 case, This week’s protein positive in 6 cases, non-secreting in 1. Determine the diagnosis of stage Ⅰ in 5 cases, Ⅱ in 4 cases, Ⅲ in 14 cases, plasma cell leukemia in 1. Transplantation Ⅰ in 8 cases, Ⅱ in 3 cases, 12 cases of stage Ⅲ, plasma cell leukemia was completely relieved.All patients underwent chemotherapy before transplantation.But the bone marrow transplant programs are not the same, but both through systemic irradiation and chemotherapy.Prevention of GVHD, including alone or in combination with MTX, CsA, McAb removal of donor T Cells and prednisone.