葡萄膜炎主要为自身免疫引起的眼内炎性疾病。内源性葡萄膜炎可严重损害视力,治疗非常困难。糖皮质激素及其它免疫抑制剂的应用虽可收到良好的效果,但这类药物需长期大剂量的应用。褐霉酸(fusidic acid)是一种具有甾类化合物为主要结构的四环三萜酸(tetracyclic triterpenoic acid),但没有糖皮质激素的副作用。这种药物通过白细胞介素干扰和妨碍了T细胞的活化,白细胞介素Ⅱ和γ-干扰素的产生减少,导致T细胞增殖减少。这与环孢霉素的作用方式非常相似,因此作者使用褐霉酸治疗严重的葡萄膜炎。 Uveitis is mainly caused by autoimmune inflammation of the eye disease. Endogenous uveitis can seriously damage vision, the treatment is very difficult. Although the application of glucocorticoid and other immunosuppressive agents can receive good results, such drugs require long-term high-dose application. Fusidic acid is a tetracyclic triterpenoic acid that has a steroid-based structure but has no side effects of glucocorticoids. This drug interferes with and disrupts T cell activation through interleukins, leading to reduced production of interleukin II and interferon-gamma, resulting in reduced T cell proliferation. This is very similar to the way cyclosporine works, so the authors used fusidic acid to treat severe uveitis.