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目的观察培哚普利和苯磺酸氨氯地平联合应用治疗高血压蛋白尿的临床疗效。方法将136例高血压合并肾脏损害蛋白尿的患者随机分为A、B两组,A组给予培哚普利4mg/d和苯磺酸氨氯地平5mg/d,B组给予苯磺酸氨氯地平5mg/d和氢氯噻嗪12.5mg/d,均治疗26周。两组治疗前及治疗后测血压、尿白蛋白、尿素氮(BUN)、血肌酐(Scr),并计算肌酐清除率(Ccr)和不良反应。结果两组治疗后6.5个月,血压较前明显下降(P<0.01),两组下降值比较差异无统计学意义(P>0.05)。两组治疗后尿蛋白均下降(P<0.05),A组降低尿蛋白作用比B组更显著(P<0.01)。A组降低Scr、BUN更显著(P<0.05)。结论培哚普利和氨氯地平联合应用能明显较平稳降低高血压,显著减少尿蛋白,有效保护肾功能。
Objective To observe the clinical efficacy of perindopril and amlodipine besylate in the treatment of hypertensive proteinuria. Methods A total of 136 hypertensive patients with renal proteinuria were randomly divided into two groups: group A received perindopril 4 mg / d and amlodipine besylate 5 mg / d, group B received ambenzene sulfonate Chlorphenamine 5mg / d and hydrochlorothiazide 12.5mg / d, were treated for 26 weeks. Before treatment and after treatment, blood pressure, urinary albumin, blood urea nitrogen (BUN) and serum creatinine (Scr) were measured in both groups, and creatinine clearance (Ccr) and adverse reactions were calculated. Results After treatment for 6.5 months, the blood pressure decreased significantly in both groups (P <0.01). There was no significant difference between the two groups (P> 0.05). The proteinuria of both groups decreased after treatment (P <0.05), and the effect of reducing proteinuria in group A was more significant than that of group B (P <0.01). A group decreased Scr, BUN more significant (P <0.05). Conclusion The combination of perindopril and amlodipine can significantly lower hypertension, reduce urinary protein and protect renal function effectively.