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AIM:To study the relationship between microvessel density(MVD),telomerase activity and biological characteristicsin hepatocellular carcinoma(HCC).METHODS:S-P immunohistochemical method andtelomeric repeat amplification protocol(TRAP)wererespectively used to analyze the MVD and telomeraseactivity in 58 HCC and adjacent normal tissues,RESULTS:The MVD in HCC with metastasis,lowerdifferentiation or without intact capsule was significantlyhigher than that in HCC with intact capsule,higherdifferentiation,or without metastasis,While MVD had norelationship with tumor size,hepatic virus infection andother clinical factors.Telomerase activity was related todifferentiation degree,but not to tumor size or histologicalgrade.MVD in HCC with telomerase activity was higherthan that in HCC without telomerase activity.CONCLUSION:MVD and telomerase activity may serveas diagnostic criteria of HCC in earlier stage.Meanwhile,there may be a cooperative effect between MVD andtelomerase on the growth and metastasis of HCC.
AIM: To study the relationship between microvessel density (MVD), telomerase activity and biological characteristics in hepatocellular carcinoma (HCC). METHODS: SP immunohistochemical method and anomeric repeat amplification protocol (TRAP) were specifically to analyze the MVD and telomerase activity in 58 HCC and adjacent normal tissues, RESULTS: The MVD in HCC with metastasis, lower differentiation or without intact capsule was significantlyhigher than that in HCC with intact capsule, higher differentiation, or without metastasis, While MVD had norelationship with tumor size, hepatic virus infection andotherclinical factors. related todifferentiation degree, but not to tumor size or histological grade. MVD in HCC with telomerase activity was higherthan that in HCC without telomerase activity. CONCLUSION: MVD and telomerase activity may serveas diagnostic criteria of HCC in earlier stage. effect between MVD andtelomerase on the growth and metas tasis of HCC.