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目的探讨辛伐他汀对脑梗死患者血清丙二醛(MDA)和超氧化物歧化酶(SOD)的影响。方法筛选68例脑梗死患者,随机分成对照组34例和治疗组34例,对照组给予脑梗死常规治疗,治疗组在常规治疗的基础上加用辛伐他汀(20 mg/d),同时筛选健康体检者34例为健康组,随访30 d。测定血清MDA、SOD含量,同时对神经功能进行评分以判断疗效。结果脑梗死患者血清MDA水平高于健康组,血清SOD含量低于健康组(P<0.05);治疗30 d,对照组及治疗组血清MDA水平均下降,SOD含量均升高(P<0.05);治疗组较对照组MDA下降更明显,SOD升高更明显,差异有统计学意义(P<0.05)。结论辛伐他汀可以下调脑梗死患者血清MDA水平,提高血清SOD水平,抵抗脑梗死后自由基损伤,改善神经功能缺损程度。
Objective To investigate the effects of simvastatin on serum malondialdehyde (MDA) and superoxide dismutase (SOD) in patients with cerebral infarction. Methods Sixty-eight patients with cerebral infarction were randomly divided into control group (34 cases) and treatment group (34 cases). The control group was given routine treatment of cerebral infarction. The treatment group was given simvastatin (20 mg / d) on the basis of routine treatment, 34 healthy subjects were healthy group, followed up for 30 days. Determination of serum MDA, SOD content, while neurological function score to determine the efficacy. Results Serum MDA levels in patients with cerebral infarction were significantly higher than those in healthy controls (P <0.05). Serum levels of MDA in control and treatment groups were decreased and SOD levels were increased at 30 d after treatment (P <0.05) ; The treatment group than the control group MDA decreased more obviously, the SOD increased more significantly, the difference was statistically significant (P <0.05). Conclusion Simvastatin can reduce the levels of MDA in serum of patients with cerebral infarction and increase the level of serum SOD, and resist the free radical injury after cerebral infarction and improve the degree of neurological deficits.