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目的 :用滞留时间法评价所得褪黑素的经皮渗透参数 ,并根据所得参数推断褪黑素能否制成经皮给药制剂。方法 :用 6个扩散池进行褪黑素体外 2 4h的经皮扩散试验 ,并计算出褪黑素的扩散系数D、分配系数Km、稳态通量Jss等参数。用滞留时间法将这些参数进行了验证。结果 :证明所得参数基本正确。结论 :褪黑素完全可以制成体外经皮给药制剂。
OBJECTIVE: To evaluate the transdermal penetration parameters of melatonin obtained by the retention time method and to deduce whether melatonin can be prepared into transdermal drug delivery according to the obtained parameters. Methods: The transdermal diffusion test of melatonin in vitro for 24 hours was performed with six diffusion cells, and the diffusion coefficient D, partition coefficient Km and steady state flux Jss of melatonin were calculated. These parameters were validated by the dwell time method. Results: Prove that the obtained parameters are basically correct. Conclusion: Melatonin can be made into an in vitro transdermal formulation.