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目的:对单纯行白内障超声乳化或者联合行雷珠单抗玻璃体腔注射用于治疗糖尿病性白内障的临床应用进行研究。方法:选取我院于2015年1月至2016年3月期间收治的糖尿病性白内障患者48例,所有患者均为增殖期糖尿病性视网膜病变,未合并黄斑水肿。将患者随机分为2组,对实验组患者行白内障超声乳化摘除并联合雷珠单抗玻璃体腔注射,对照组患者行白内障超声乳化摘除;并对两组患者的最佳矫正视力、黄斑区视网膜厚度以及眼压等指标进行观察。结果 :两组患者的术前和术后1mo黄斑区下视网膜厚度以及最佳矫正视力无差异;术后6mo对照组的最佳矫正视力低于实验组,黄斑区下视网膜厚度厚于实验组(P<0.05),且实验组出现黄斑水肿的比率为12.5%,同对照组相比明显较低(45.8%)。结论 :白内障超声乳化联合雷珠单抗玻璃体腔注射对糖尿病性白内障进行治疗,能够提高患者术后最佳矫正视力,降低术后的黄斑水肿发展。
Objective: To study the clinical application of simple cataract phacoemulsification combined with intravitreal injection of ranibizumab in the treatment of diabetic cataract. Methods: Forty-eight patients with diabetic cataract who were treated in our hospital from January 2015 to March 2016 were enrolled. All patients had proliferative diabetic retinopathy without macular edema. The patients were randomly divided into two groups, the experimental group of patients underwent cataract phacoemulsification combined with intravitreal injection of rosiglitazone, the control group underwent cataract phacoemulsification; best correction of visual acuity in both groups, macular retinal Thickness and intraocular pressure and other indicators were observed. Results: There was no difference between the two groups in preoperative and postoperative 1mo macular retinal thickness and best corrected visual acuity. The best corrected visual acuity of the control group was lower than that of the experimental group at 6 months after operation, and the thickness of the retina in the macular area was thicker than that of the experimental group P <0.05), and the rate of macular edema in experimental group was 12.5%, which was significantly lower than that in control group (45.8%). Conclusion: Cataract phacoemulsification combined with intravitreal injection of ranibizumab for diabetic cataract can improve the best corrected visual acuity and reduce the development of postoperative macular edema.