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作者报道经2年以上治疗的小儿白血病和淋巴瘤31例,用长春新碱(VCR)治疗后引起发热。其中急性淋巴细胞白血病(ALL)22例,急性非淋巴细胞白血病(ANLL)3例,非何杰金淋巴瘤(NHL)6例。确诊时平均年龄为5.8岁(7个月-15岁)。维持治疗分3组:A组静注VCR加6-巯嘌呤(6-MP)及强的松龙(Pred)内服5天;B组以氨甲喋呤(MTX)内服4天后静注VCR;C组为VCR与柔红霉素(DNR)、环磷酰胺(CPM)、阿糖胞苷(Ara-c)及Prcd并用。VCR为2mg/M~2,稀释成0.4mg/ml静注。VCR所致发热为使用VCR后48小时内出现发热,体温超过37℃且持续6小时以上,无任何感染的症状和体征。本组31例中有9例在注射VCR后出现2次以上的发热(30%),ALL中有8/22例(36.4%),AML
The authors report 31 cases of pediatric leukemia and lymphoma treated over 2 years, with fever induced by treatment with vincristine (VCR). Among them, 22 cases were acute lymphoblastic leukemia (ALL), 3 cases were acute non-lymphocytic leukemia (ANLL) and 6 cases were non-Hodgkin lymphoma (NHL). The average age at diagnosis is 5.8 years (7 months-15 years). Maintenance treatment was divided into 3 groups: Group A received intravenous VCR plus 6-mercaptopurine (6-MP) and prednisolone (Pred) for 5 days; Group B received intravenous methotrexate (MTX) VCR and daunorubicin (DNR), cyclophosphamide (CPM), cytarabine (Ara-c) and Prcd combined. VCR 2mg / M ~ 2, diluted to 0.4mg / ml intravenous injection. VCR-induced fever was fever within 48 hours of VCR use, with body temperature over 37 ° C for more than 6 hours without any signs and symptoms of infection. In this group, 9 of 31 patients developed fever more than twice (30%) after VCR injection, 8/22 (36.4%) ALL patients, AML