假说最近,Goldie和Coldman(1983)提出肿瘤细胞中存在干细胞与干细胞的区别。1983年Mackillop等提出正常组织中细胞更新(renewal)的等级同样存在于原发性肿瘤之中。他们认为整个肿瘤细胞群中有3种细胞类型:(a)非增殖的、已分化的(终末)细胞,(b)增殖的、非更新(过渡性)细胞及(c)增殖的、自我更新的(干)细胞。1984年,作者提出化疗可治愈的肿瘤仅仅是含有可限性自我更新能力的定向祖细胞, Hypotheses Recently, Goldie and Coldman (1983) suggested that there is a distinction between stem cells and stem cells in tumor cells. In 1983, Mackillop et al proposed that the level of renewal of cells in normal tissues is also present in primary tumors. They consider three cell types in the entire tumor cell population: (a) nonproliferative, differentiated (terminal) cells, (b) proliferating, non-renewal (transitional) cells and Updated (dry) cells. In 1984, the authors suggested that chemotherapy-curable tumors are merely committed progenitor cells with limited self-renewal capacity,