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目的:本研究以神经性毒剂降解产物为模板分子,在不同反应条件下合成了系列分子烙印聚合物 (MIP)作为固相萃取(SPE)填料,以评价和研制一种神经性毒剂降解产物的选择性吸附剂,并研究其吸附机制和影响因素。方法:分别以VX的水解产物甲基膦酸乙酯(EMPA)、俄罗斯VX的水解产物甲基膦酸异丁酯 (i BuMPA)和梭曼的水解产物甲基膦酸片呐酯(PMPA)为模板分子合成MIP,并填充自制MIP SPE小柱,气相色谱检测,考察功能单体、交联剂、溶剂、温度及MIP粒子的大小等因素对MIP吸附性能的影响。结果:实验表明功能单体和交联剂的种类和用量及模板分子的结构是影响MIP吸附性能的重要因素。以丙烯酰胺为功能单体、乙二醇二甲基丙烯酸酯为交联剂合成的MIP适用于对神经性毒剂降解产物吸附行为的考察。以神经性毒剂降解产物为模板分子合成的MIP对各降解产物均呈现较强的吸附,其吸附率与降解产物的结构呈一定相关性。结论:合成的系列MIP可作为通用的神经性毒剂降解产物的选择性吸附剂,用于对样品中神经性毒剂降解产物的萃取。
OBJECTIVE: In this study, a series of molecular imprinting polymers (MIPs) were synthesized as solid phase extraction (SPE) filler under different reaction conditions using neurotoxic agent degradation products as template molecules to evaluate and develop a degradation product of neurotoxic agents Selective adsorbent, and study its adsorption mechanism and influencing factors. Methods: Ethylhexyl methylphosphonate (EMPA), a hydrolyzate of VX, isobutyl methylphosphonate (i BuMPA), a hydrolyzate of VX from Russia, and PMPA, a hydrolyzate of soman, The MIPs were synthesized for the template molecules and filled with home-made MIP SPE cartridges. Gas chromatography was used to examine the influence of MIP on the adsorption properties of MIPs, such as functional monomer, cross-linking agent, solvent, temperature and MIP particle size. Results: Experiments show that the type and amount of functional monomers and cross-linking agents and the structure of template molecules are important factors that affect MIP adsorption performance. The MIP synthesized by using acrylamide as the functional monomer and ethylene glycol dimethacrylate as the crosslinking agent is suitable for the investigation of the adsorption behavior of the degradation product of the nerve agent. MIPs synthesized from neurotoxic agent degradation products showed strong adsorption on all degradation products, and the adsorption rate was related to the structure of degradation products. Conclusion: The synthetic MIP can be used as a selective adsorbent for the degradation products of neurotoxic agents. It can be used for the extraction of neurotoxic agents degradation products in samples.