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近年来在肿瘤免疫治疗中,常用患者对某些种抗元的皮肤迟发超敏反应性,以检测机体免疫反应性的改变。我们在用自体瘤苗免疫治疗过程中,曾对一部分癌瘤患者作结核菌素皮肤迟发超敏反应试验,以观察其免疫反应性的变化,并进行随查。通过半年到一年半的随查结果,初步认为机体免疫反应性维持时间的长短,是取决于瘤灶切除的彻底与否,以及患者原有免疫力的强弱。如原有免疫力很差时,就更需要手术切除的彻底,不然仅靠免疫治疗来提高疗效是不够的。另外,我们应用此法又初步观察部分癌瘤病人,术前后的皮肤迟发超敏反应性的改变。
In recent years, in the immunotherapy of tumors, patients often use delayed hypersensitivity on certain skin types to detect changes in immune response. In the course of immunotherapy with autologous tumor vaccines, we conducted a tuberculin skin delayed hypersensitivity test on a subset of cancer patients to observe changes in their immunoreactivity and conduct follow-up investigations. After six months to one and a half years of investigations, it was initially thought that the length of time the body’s immune response was maintained depended on the complete removal of the tumor focus and the strength of the patient’s existing immunity. If the original immune system is very poor, it will require a complete surgical resection. Otherwise, it is not enough to rely on immunotherapy alone to improve the therapeutic effect. In addition, we applied this method and initially observed some patients with cancer, before and after the skin changes in hypersensitivity.