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目的：探讨宫内膜良恶性病变癌基因ｃ－ｅｒｂＢ－２和ＰＣＮＡ阳性细胞体数密度有无明显差别。方法：应用免疫组化技术对１０８ 例宫内膜增生过长、宫内膜癌中癌基因ｃ－ｅｒｂＢ－２、ＰＣＮＡ表达的阳性细胞进行体视学计数。结果：在宫内膜恶性病变中两者阳性细胞的体数密度明显高于良性病变，差别有统计学意义（Ｐ＜ ０．０１）。结论：测定ｃ－ｅｒｂＢ－２和ＰＣＮＡ阳性细胞体数密度可以作为临床判断宫内膜病变良恶性的辅助指标
Objective: To investigate whether endometrial benign and malignant lesions of c-erbB-2 and PCNA-positive cell number density were significantly different. Methods: 108 cases of endometrial hyperplasia, endometrial cancer oncogene c-erbB-2, PCNA positive cells were stained with stereology. Results: The body density density of positive cells in endometrial malignant lesions was significantly higher than that in benign lesions, the difference was statistically significant (P <0.01). Conclusion: The determination of c-erbB-2 and PCNA-positive cell number densities can be used as a secondary indicator of benign and malignant endometrial lesions