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目的探讨预制型无机诱导因子复合性工程支架材料在骨大型缺损中的修复能力,及放射性核素显像技术在此过程中的应用价值。方法实验山羊15只按第4、8、12周时间点分为3组。采用自身配对设计,左侧置入支架材料,右侧空白对照。术后4、8、12周分别通过放射性核素99mTc-MDP骨显像进行监测。结果放射性核素骨显像中感兴趣区(ROI)计数和摄取比值显示:对照组在3个时间点均未见明显核浓聚性的再血管化及明显成骨现象,而实验组则随时间呈单驼峰状,在8周时达峰值,而到12周时血管化已完成,转为以成骨为主,故出现ROI和摄取比值的轻度下降趋势。结论99mTc-MDP监测到新生骨的良好成骨效能和再血管化状况,是一种较好的骨组织工程构建骨的监测手段。
OBJECTIVE: To investigate the repairing ability of precast inorganic inducer composite engineering scaffolds in large bone defects and the application value of radionuclide imaging in this process. Methods 15 goats were divided into 3 groups according to the 4th, 8th and 12th week points. Using its own paired design, the left into the stent material, the right blank control. At 4, 8 and 12 weeks after operation, radionuclide 99mTc-MDP bone imaging was performed respectively. Results The areas of interest (ROI) count and uptake ratio in radionuclide bone imaging showed that in the control group, no obvious nuclear agglomeration of vascularization and obvious osteogenesis were observed in the control group, while in the experimental group, The time was single hump shape, peaked at 8 weeks, but by the end of 12 weeks, the vascularization was completed and became the main osteogenesis. Therefore, there was a slight downward trend in ROI and uptake ratio. Conclusion 99mTc-MDP can detect the good osteogenesis and revascularization of newborn bone, which is a good method of bone tissue engineering.