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目的:观察木芙蓉叶有效部位(MFR-C)的抗炎与镇痛药效学结果。方法:以盐酸青藤碱组和空白组为对照,口服灌胃不同剂量 MFR-C,分别进行小鼠腹腔毛细血管通透性实验、小鼠耳肿胀实验及小鼠扭体实验。结果:。(1)MFR-C 抑制小鼠腹腔毛细血管通透率为30.4%,与空白对照组比较,抑制渗出作用差异有显著性(P<0.05);(2)小鼠耳肿胀实验显示 MFR-C 有抑制二甲苯造成的非特异性耳肿胀的作用,与空白对照组比较,差异有显著性(P<0.05),与盐酸青藤碱组作用相似;(3)MFR-C 具有镇痛作用,可减少小鼠扭体数,与空白对照组比较,差异有显著性(P<0.05)。结论:MFR-C 具有良好的抗炎与镇痛作用。
Objective: To observe the anti-inflammatory and analgesic effects of MFR-C. METHODS: The sinomenine hydrochloride group and blank group were used as control, and different doses of MFR-C were orally administered by gavage. The mice were subjected to abdominal capillary vascular permeability test, mouse ear swelling experiment and mouse writhing experiment. result:. (1) MFR-C inhibited the capillary permeability of the abdominal cavity in mice was 30.4%. Compared with the blank control group, there was a significant difference in the inhibition of exudation (P<0.05); (2) Mouse ear swelling test showed MFR- C inhibited the non-specific ear swelling caused by xylene, compared with the blank control group, the difference was significant (P <0.05), similar to the effect of sinomenine hydrochloride group; (3) MFR-C has analgesic effect, The number of writhing of the mice was reduced, compared with the blank control group, the difference was significant (P<0.05). Conclusion: MFR-C has good anti-inflammatory and analgesic effects.