In this article, we review the current knowledge of the glacial recession and related glacial lake development in the Andes of South America. Since the mid-1980s, hundreds of glacial lakes either expanded or formed, and predictions show that additional hundreds of lakes will form throughout the 21st century. However, studies on glacial lakes in the Andes are still relatively rare. Many glacial lakes pose a potential hazard to local communities, but glacial lake outburst floods (GLOFs) are understudied. We provide an overview on hazards from glacial lakes such as GLOFs and water pollution, and their moni- toring approaches. In real-time monitoring, the use of unmanned aerial systems (UASs) and early warning systems (EWSs) is still extremely rare in the Andes, but increasingly authorities plan to install mitigation systems to reduce glacial lake risk and protect local communities. In support, we propose an international remote sensing-based observation initiative following the model of, for example, the Global Land Ice Measurements from Space (GLIMS) one, with the headquarters in one of the Andean nations.