全身性红斑狼疮(SLE)临床表现有发热,发诊、关节痛并伴育血清免疫学异常。例如能检出抗核抗体、抗DNA抗体、LE细胞等。通常认为是自家免疫性疾病。非SLE患者由于使用某些药物也出现发热、发疹、关节痛及其它类似SLE表现,这种疾病称为药物引起的红斑狼疮综合征(DLS)。引起DLS的药物很多。最常见的有:肼苯达嗪、普鲁卡因酰胺、抗惊厥药、异烟肼、氯丙嗪、口服避孕药等。由于药物种类不同,表现不同的症状。如普鲁卡因酰胺引起的DLS常有心、肺、胸膜病变,肼苯达嗪引起的DLS则肾疾患较多。DLS的自家免疫的发病机制有如下几方面: (1)药物损害机体的免疫组织,使免疫调节系统破坏,产生自家抗原的免疫反 Clinical manifestations of systemic lupus erythematosus (SLE) are fever, hair consultation, joint pain and immune serum abnormalities. For example, antinuclear antibodies, anti-DNA antibodies, LE cells and the like can be detected. It is usually considered as an autoimmune disease. Non-SLE patients also experience fever, rash, joint pain and other similar SLE manifestations due to the use of certain medications called drug-induced lupus syndrome (DLS). Drugs that cause DLS are numerous. The most common are: hydralazine, procainamide, anticonvulsants, isoniazid, chlorpromazine, oral contraceptives and so on. Due to the different types of drugs, the performance of different symptoms. Such as procaine amide caused by DLS often heart, lung, pleural disease, hydralazid-induced DLS renal disease more. The pathogenesis of DLS autoimmune has the following aspects: (1) the drug damage the body’s immune tissue, so that the immune regulatory system damage, the anti-immune