口眼干燥、关节炎综合征又称Sj ogren综合征(以下简称SS),是以口眼干燥、腮腺肿大和结缔组织病为主的综合征。其结缔组织病以类风湿性关节炎(RA)最为多见,此外,也可伴有系统性红斑狼疮(SL E)、硬皮病、皮肌炎、结节性多动脉炎、多发性肌炎、慢性活动性肝炎、慢性淋巴细胞性甲状腺炎(又称桥本氏病)、纤维素性肺泡炎、间质性肾炎、Waklenstrom巨球蛋白血症、冷球蛋白血症等疾病。 SS患者的血清中可检到多种自身抗体,因而被认为是一种自身免疫病(以下简称AID)。本病在临床上并不少见,且其确切病因尚未阐明,因而治疗上颇为辣手,涉及的面也很广,亟应加以研究。简史 1933年瑞典眼科医生Henrick Sjogren报道了19例以干性角膜结合膜炎、口干、涎腺肿大和多发性关节炎为主征的病例,并发现大多数为妇女,约半数患者合并有结缔组织 Dry mouth, arthritis syndrome, also known as Sj ogren syndrome (hereinafter referred to as SS), is based on dry mouth, parotid gland enlargement and connective tissue disease-based syndrome. Its connective tissue disease is most commonly seen with rheumatoid arthritis (RA) and may be accompanied by systemic lupus erythematosus (SLE), scleroderma, dermatomyositis, polyarteritis nodosa, multiple myenteric Inflammation, chronic active hepatitis, chronic lymphocytic thyroiditis (also known as Hashimoto’s disease), cellulose alveolitis, interstitial nephritis, Waklenstrom macroglobulinemia, cryoglobulinemia and other diseases. SS patients sera can detect a variety of autoantibodies, it is considered an autoimmune disease (hereinafter referred to as AID). The disease is not uncommon in clinical practice, and its exact cause has not yet been elucidated, so the treatment is quite hot, involving a wide range of aspects, it is imperative to be studied. A brief history In 1933 Swedish ophthalmologist Henrick Sjogren reported 19 cases of dry corneal conjunctivitis, dry mouth, salivary gland enlargement and multiple arthritis mainly levy cases and found that most of the women, about half of patients with a combination of Connective tissue