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卵子成熟障碍发生于体外受精技术的促排卵过程中,如果反复发生且不能通过卵子体外成熟培养来解决时,即称为卵子成熟障碍综合症。根据卵子减数分裂阻滞在不同的时期将卵子成熟障碍综合症分为GV期阻滞、MI期阻滞、MII期阻滞和混合型阻滞。目前认为,卵子体内成熟过程中的不同时期的主要信号传导通路障碍,将导致不同类型的卵子成熟障碍的发生。
Egg maturation disorder occurs during ovulation induction by in vitro fertilization. If it occurs repeatedly and can not be solved by oocyte maturation in vitro, it is called egg maturation disorder. According to the oocyte meiosis arrest in different stages of the egg mature disorder is divided into GV phase arrest, MI phase arrest, MII phase arrest and mixed block. It is currently believed that the major signaling pathways at different stages of egg maturation in vivo will result in the development of different types of egg maturation disorders.