【摘 要】
：
目的 观察不同粒径二氧化硅颗粒对大鼠肺组织的急性毒性.方法 将105只大鼠随机分为7组,每组15只,分别给予20、50、80、140、280、800 nm SiO2颗粒,浓度为400mg/m3.对照组不给
【机 构】
：
上海计划生育科学研究所,广西中医学院,上海医药工业研究院,上海中医药大学
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目的 观察不同粒径二氧化硅颗粒对大鼠肺组织的急性毒性.方法 将105只大鼠随机分为7组,每组15只,分别给予20、50、80、140、280、800 nm SiO2颗粒,浓度为400mg/m3.对照组不给予粉尘颗粒,各组动物在相同条件下静态吸入染尘2 h后,在24、48、72 h后处死大鼠测定肺泡灌洗液(BALF)中细胞总数、总蛋白含量和乳酸脱氢酶(LDH)活力,并进行肺组织病理观察.结果 与对照组[(0.08±0.02)g/g]比较,800 nm组除72 h总蛋白含量[(0.25±0.01)g/L]明显升高,差异有统计学意义(P0.05).280mm组各时间细胞总数、总蛋白含量和LDH活力均明显高于对照组,差异有统计学意义(P
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