酸敏感离子通道(acid-sensing ion channels,ASICs)是一类由氢离子(H+)激活的配体门控阳离子通道,是上皮钠离子通道/退化蛋白(ENaC/DEG)超家族一个分支。1980年Krishtal等[1]在神经元上首次记录到了一种被H+激活的阳离子电流,猜测细胞膜上可能存在质子受体。1997年Waldmann等[2]克隆了第1个被酸激活的通道蛋白,将其命名为酸敏感离子通道(acid-sensing ion channels,ASICs)。此后,人们对ASICs的研究进展也更加迅速。在啮齿类动 Acid-sensing ion channels (ASICs) are a class of ligand-gated cation channels activated by hydrogen ions (H +), a branch of the epithelial sodium ion channel / degeneration protein (ENaC / DEG) superfamily. Krishtal et al. [1] first reported a cation current activated by H + in neurons in 1980, and speculated that there may be proton receptors on the cell membrane. In 1997, Waldmann et al [2] cloned the first acid-activated channel protein, named acid-sensing ion channels (ASICs). Since then, research on ASICs has progressed more rapidly. In rodents