目的:评价危重患儿口腔护理相关临床实践指南的质量，为危重患儿口腔护理实践提供建议。方法:计算机检索国内外电子文献数据库、指南网站及相关专业协会网站中与危重患儿口腔护理相关的临床实践指南，检索时限为2009年1月1日至2021年1月1日。采用临床指南研究与评估工具（AGREE Ⅱ）对指南进行质量评价，对纳入指南的推荐意见进行提取、归类、分析。结果:共纳入9篇指南，总体质量评价为A级2篇，B级7篇。9篇指南在AGREE Ⅱ 6个领域的平均标准化得分由高到低依次为范围和目的94.32%、清晰性92.97%、编辑独立性77.78%、参与人员74.89%、制订严谨性73.84%、应用性61.32%。结论:纳入的危重患儿口腔护理相关临床实践指南整体质量较高，指南的应用性、制订严谨性等仍有待提高。目前我国尚无针对危重患儿口腔护理的临床实践指南，可考虑将国外指南进行跨文化调试，以指导我国危重患儿口腔护理实践规范。“,”Objective:To evaluate the quality of clinical practice guidelines related to oral care for critically ill children, so as to provide recommendations for oral care practice in critically ill children.Methods:Clinical practice guidelines related to oral care for critically ill children were retrieved by computer in electronic literature databases at home and abroad, guideline websites and related professional association websites. The search time limit was from January 1, 2009 to January 1, 2021. The quality of the guidelines was evaluated by the Appraisal of Guidelines for Research and Evaluation (AGREE Ⅱ) , and the recommendations of the included guidelines were extracted, classified and analyzed.Results:A total of 9 guidelines were included. The overall quality evaluation showed that 2 articles were grade A, and 7 articles were grade B. The average standardized scores of the 9 guidelines in the 6 fields of AGREE Ⅱ from high to low were 94.32% for scope and purpose, 92.97% for clarity of presentations, 77.78% for independence, 74.89% for stakeholder involvement, 73.84% for rigor of development, and 61.32% for applicability.Conclusions:The overall quality of the clinical practice guidelines related to oral care for critically ill children is high, but the applicability and the rigor of development of the guidelines still need to be improved. At present, there is no clinical practice guideline on oral care for critically ill children in China, and cross-cultural adjustment of foreign guidelines can be considered to guide the practice of oral care for critically ill children in China.