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目的探讨拨云滴眼剂对家兔金黄色葡萄球菌角膜炎的治疗作用。设计实验研究。研究对象角膜感染金黄色葡萄球菌的家兔。方法将家兔角膜刮痕后接种金黄色葡萄球菌,分别用复方熊胆滴眼液、高、中、低浓度的拨云滴眼剂进行治疗,以拨云滴眼剂溶剂组和不给药组为对照。主要指标观察家兔结膜和角膜病变。结果结膜病变情况:复方熊胆滴眼液组、高、中、低浓度的拨云滴眼剂组与溶剂组无显著性差异;高浓度拨云滴眼剂组在第1、3、4和5天,中浓度拨云滴眼剂组存第1和4天,低浓度拨云滴眼剂组在第1、2和4天,与不给药组有显著性差异。角膜病变:高浓度拨云滴眼剂组在第1、3、4和5天,中浓度拨云滴眼剂组在第1、3、4、5和7天,低浓度拨云滴眼剂组在第3天,与溶剂组有显著性差异;复方熊胆滴眼液组在第1、4、5和6天与不给药组有显著性差异;高浓度拨云滴眼剂组在第1、3、4、5、6、7和8天,中浓度拨云滴眼剂组在第1、3、4、5、6、7、8和9天,低浓度拨云滴眼剂组在第5、6、7和8天,与不给药组有显著性差异。复方熊胆组、滴剂组、高浓度组、中浓度组、低浓度组和不给药组角膜培养的金黄色葡萄球菌阳性率分别为50.0%、33.3%、25.0%、16.7%、58.3%和50.0%。结论拨云滴眼剂治疗家兔金黄色葡萄球菌角膜炎有效。(眼科,2007,16:425-427)
Objective To investigate the therapeutic effect of Dipyun Eye Drops on rabbit Staphylococcus aureus keratitis. Design experimental studies. Study subjects were infected with Staphylococcus aureus in rabbits. Methods The rabbits were inoculated with Staphylococcus aureus after scratching the cornea. They were treated with compound Xiongdan eye drops, high, medium and low concentrations of dialyrin eye drops, respectively. The group is a control. Main indicators Observed rabbit conjunctiva and keratopathy. Results Conjunctival lesions: There was no significant difference between the compound bear bile eye drops group, the high, medium, and low concentrations of dialyrin eye drops and the solvent group; the high concentration of eye drop eye drops was in the first, third, and fourth. On the 5th day, the medium concentration dialyrin eyedrops group stored on the 1st and 4th days, and the low concentration dialyzed eye drops group on the 1st, 2nd and 4th days, and the non-administration group had significant difference. Corneal Lesions: High Concentrated Cloud Eye Drops Group on Days 1, 3, 4 and 5, Medium Concentration Cloud Eye Drops Group on Days 1, 3, 4, 5 and 7 and Low Concentration Eye Drops On the 3rd day, there was a significant difference between the group and the solvent group. There was a significant difference between the compound bear bile eye drops group on days 1, 4, 5, and 6 and the non-drug group. On Days 1, 3, 4, 5, 6, 7 and 8 of the medium-dose concentrated cloud eye drops group on days 1, 3, 4, 5, 6, 7, 8 and 9 days, low-dose extractive eye drops There were significant differences between the groups on the 5th, 6th, 7th and 8th days in the non-administered group. The positive rate of Staphylococcus aureus in the cornea culture of compound bear bile group, drop group, high concentration group, medium concentration group, low concentration group and non-administration group were 50.0%, 33.3%, 25.0%, 16.7%, 58.3%, respectively. And 50.0%. Conclusion Dianyun eye drops is effective for the treatment of rabbit Staphylococcus aureus keratitis. (Ophthalmology, 2007, 16:425-427)