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骨质疏松症(OP)是多种因素导致的复杂疾病,它的发生与峰值骨量高低和骨量丢失速度密切相关,而遗传与环境因素参与了峰值骨量的达到、维持以及骨量丢失的调节。研究证实,遗传因素可解释60％～80％骨密度(BMD)的变化。近年来, 对导致OP相关基因的研究成为热点,目前已对约 60种与骨代谢有关的基因及其多态性与骨质疏松表型的关系进行了研究。这些候选基因中,VDR、 ER、COLIAl、白介素家族(IL-lra,6,11)、胰岛素样生长因子IGF-1、骨钙素、降钙素及其受体、 TNFα等基因的研究报道较多,本文对另几个候选基因的研究现状作一综述。
Osteoporosis (OP) is a complex disease caused by many factors, its occurrence is closely related to the peak bone mass and the rate of bone loss, while genetic and environmental factors are involved in the peak bone mass, maintenance and bone loss Adjustment. Studies confirm that genetic factors can explain the 60% to 80% change in bone mineral density (BMD). In recent years, research on OP-related genes has become a hot spot. At present, about 60 genes related to bone metabolism and their polymorphisms have been studied in relation to osteoporosis phenotypes. Among these candidate genes, studies on genes such as VDR, ER, COLIA1, interleukin family (IL-lra, 6,11), insulin-like growth factor IGF-1, osteocalcin, calcitonin and their receptors, In this paper, we reviewed the current research status of several other candidate genes.