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1 本类药物系喹诺酮分子的6位升入氟,7位引入哌嗪的第三代新合成抗菌药,现已用于临床的有2氟哌酸、氟啶酸、氟嗪酸、环丙氟哌酸等。现以氟嗪酸为倒作介绍。 1.1 本品为新型广谱高效杀菌剂,对厌氧菌、革兰氏阳性和阴性细菌、葡萄球菌、溶血性链球菌和肠球菌的抗菌活性比氟哌酸(诺氟沙星)强4~8倍,较吡哌酸、萘啶酸强32~256倍,对支原体、衣原体、结核菌、流感杆菌等均有强大的作用。对绿脓杆菌作用略弱于氟啶
1 This class of drugs Department of quinolone molecule into the fluorine 6, 7 into the third generation of piperazine new synthetic antibacterial drugs, is now used in clinical 2 norfloxacin, fludic acid, ofloxacin, cyclopropane Norfloxacin and so on. Now to the introduction of trimethoprim acid. 1.1 This product is a new broad-spectrum high-performance fungicide against Anaerobic bacteria, Gram-positive and negative bacteria, Staphylococcus aureus, Streptococcus hemolyticus and enterococci antibacterial activity than norfloxacin (norfloxacin) 8 times more than pipemidic acid, nalidixic acid strong 32 ~ 256 times, Mycoplasma, Chlamydia, Mycobacterium tuberculosis, influenza, etc. have a strong role. The role of Pseudomonas aeruginosa is slightly weaker than fluoride